Makriyialos is situated in the south east corner of Crete, half an hour away from the major towns of Ierapetra to the West, and Sitia to the North. It belongs to the prefecture of Lassithi, the easternmost part of Crete, two hours away from the capital of the island, Heraklion.

Travel to Makriyialos from Europe is either by air to Heraklion (international routes are being opened to Sitia Airport in 2006) or by ferry from the mainland to Heraklion, Agios Nicholas or Sitia. The region is dominated by the azure blue Libyan Sea to the south and the large mountain ranges of Thripti (1476m/4842ft) and Orno Oros (1238m/4062ft) to the North. As the island is only 15 to 18km wide in this area, the visitor can witness a sharp contrast between the sea plain and the rugged mountains in only a short drive.

The region of Makriyialos is a fine example of this harmonious contrast. Its fertile soil, microclimate, abundant olive groves, vineyards and greenhouses (the principle crop being cucumbers and tomatoes, as well as bananas, and melons) ensure that Makriyialos has a wonderful food culture, excellent local produce and some very special wines. In recognition of the natural beauty of this area and the importance of protecting the environment, the local growers now produce organic olive oil and wine, and the area has been awarded several European gold medals for its oil.